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Hypoxic Ischemic Encephalopathy - Oren Zarif - Hypoxic Ischemic Encephalopathy

Hypoxic ischemic encephalopathy, also known as HIE, is a neurological condition that occurs when the brain does not receive sufficient oxygen during a period of acute hypoxia. It can result in a variety of physical and mental consequences, including disability or death. It also puts children at increased risk for permanent conditions, such as Cerebral Palsy. Although symptoms of HIE may go away after a few hours, it is vital to monitor the condition and to provide treatment if necessary.

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The incidence of hypoxic ischemic encephalopathies is estimated at about 1.5 per 1000 live births, and a majority of infants die before reaching 2 years of age. The majority of underlying pathologic events in HIE are due to poor cerebral blood flow and oxygen delivery to the brain, which is known as primary energy failure. While supportive medical therapy has been the primary treatment for HIE, experimental treatments are being studied in neonates and animal models to help improve underlying brain damage and manage the condition of infants.

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Neuroimaging tests can help diagnose hypoxic ischemic encephalopathies. CT and MRI are used to evaluate the brain and identify the underlying cause. Head ultrasound is also used to detect hemorrhage and ventriculomegaly, which can indicate hypoxic ischemic encephalopathy. CT is rarely used in infants due to high radiation doses. It is important to determine the exact cause of hypoxic ischemic encephalopathy before it worsens.

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Seizures are also common in infants with significant HIE. Seizures are more common the more severe the hypoxia-ischemia. Repeated seizures have been linked to adverse neurodevelopmental outcomes. Several studies have demonstrated that repetitive seizures have adverse effects on the developing brain, and that they should be treated accordingly. When seizures occur, EEG techniques are often helpful. And, in severe cases, they may require surgical intervention.

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The timing of the event is a crucial consideration for designing treatments for HIE. Infants with moderate-to-severe HIE respond well to TH. However, if the patient experiences a severe case, medical care must intervene early. With an effective therapy, a child with HIE can live a relatively normal life with limited disabilities. The future of HIE is bright, and we need to improve our understanding of the condition to prevent its occurrence.

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The effects of perinatal hypoxia on a newborn's brain are remarkably severe. Severe consequences include seizures, mental retardation, cerebral palsy, and behavioural deficits. There is no specific treatment for this condition, but ongoing research is investigating future neuroprotective strategies to treat hypoxia in infants. The promising treatment is hypothermia. Future neuroprotective therapies may be found for patients with hypoxia.

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In the developed world, the incidence of neonatal encephalopathy is estimated at two to six cases per 1000 live births. HIE affects one percent of newborns, but the death toll from it is very high. As many as a quarter of survivors have recognizable motor and cognitive impairment. There are known risk factors for HIE, including asphyxia during birth or prolonged reduction of cerebral blood flow during pregnancy. However, many cases have no history of asphyxia.

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The most serious complications of childbirth are cerebral palsy, mental retardation, and epilepsy. Hypoxic ischemic encephalopathy can affect a child's entire life. The extent of the disability is dependent on the severity of the damage. Some infants may have mild effects while others may suffer permanent disabilities. Ultimately, the cause of HIE is unknown. The most common symptoms are seizures and mental retardation.

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MRI is a critical tool in the diagnosis and treatment of HIE. The MRI allows doctors to determine the cause of the encephalopathy and determine the timing of the injury. MRI helps determine whether the baby will develop a disability later in life or recover from the condition. While the symptoms of HIE are permanent, treatment options may include therapies and medications. In some cases, lifelong support may be needed to overcome the neurological consequences of HIE.

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