What is Acute Cerebral Ischemia? - Oren Zarif - Cerebral Ischemia
Acute cerebral ischemia is a condition that causes brain damage and is characterized by decreased cerebral blood flow. Normal cerebral blood flow (CBF) is around 50 mL per 100 g per minute. When CBF falls below twenty to twenty-five, there is EEG evidence of ischemia. Below ten, neuronal death begins rapidly. The characteristic EEG pattern of a patient with focal cerebral ischemia is an area of severe ischemia with a surrounding area of moderate ischemic brain injury. The clinical findings of this condition are consistent with a brain infarction.
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Local cortical activity ceases within seconds of the onset of acute cerebral ischemia. Global ischemia leads to unconsciousness. The rapid shut-down of neural activity results from massive K+ efflux from neurons, mediated by ATP-dependent and voltage-dependent K+ channels. This influx of K+ causes a transient hyperpolarization of the plasma membrane. When the plasma membrane depolarizes, there is a dramatic redistribution of ions across the brain.
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Untreated heart attacks, stroke, or a blood clot can all cause cerebral ischemia. When the blood flow is slowed, a clot forms in the arteries, blocking oxygen from reaching the brain. People with congenital heart defects are more susceptible to blood clots. Another cause is anemia, which is a disorder of hemoglobin, the oxygen-carrying part of red blood cells.
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People with sickle-cell anemia have irregular-shaped red blood cells that tend to clot easily.
If untreated, the consequences of cerebral ischemia are devastating. Patients can suffer from cardiorespiratory arrest, permanent brain damage, or even death. There are several causes of cerebral ischemia, ranging from congenital heart defects to sickle cell anemia. If you think you have this condition, consult a doctor right away to determine the best course of action. You could be one of the many people who suffer a stroke.
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To better understand cerebral ischemia, you need to know more about its anatomy and the effects it has on brain function. MRI can identify cerebral ischemia, including ischemic stroke. If a patient suffers from cerebral ischemia, he or she may benefit from a drug that improves brain function. However, if you suspect you have ischemia, consult your doctor before administering it to your patient.
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Untreated heart attacks, stroke, or a blood clot can all cause cerebral ischemia. When the blood flow is slowed, a clot forms in the arteries, blocking oxygen from reaching the brain. People with congenital heart defects are more susceptible to blood clots. Another cause is anemia, which is a disorder of hemoglobin, the oxygen-carrying part of red blood cells.
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People with sickle-cell anemia have irregular-shaped red blood cells that tend to clot easily.
If untreated, the consequences of cerebral ischemia are devastating. Patients can suffer from cardiorespiratory arrest, permanent brain damage, or even death. There are several causes of cerebral ischemia, ranging from congenital heart defects to sickle cell anemia. If you think you have this condition, consult a doctor right away to determine the best course of action. You could be one of the many people who suffer a stroke.
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To better understand cerebral ischemia, you need to know more about its anatomy and the effects it has on brain function. MRI can identify cerebral ischemia, including ischemic stroke. If a patient suffers from cerebral ischemia, he or she may benefit from a drug that improves brain function. However, if you suspect you have ischemia, consult your doctor before administering it to your patient.
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