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TPA and Acute Ischemic Stroke - Oren Zarif - TPA Stroke

Writer's picture: Oren ZarifOren Zarif

To develop a clinical evidence-based guideline for tPA for acute ischemic stroke, the American College of Emergency Physicians and the Academy of Neurology have established a joint development panel. The panel's mandate is to "assess the efficacy and safety of tPA in the treatment of acute ischemic stroke."

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The study, conducted over two years, examined data from a multicenter study of TPA and acute ischemic stroke. It included 2,317 patients with acute ischemic stroke. The patients had higher initial severity of stroke and were more likely to have other medical comorbidities. However, despite this high level of patient inclusion, tPA was still only administered to 27% of patients who presented to the hospital within 3 hours.

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The new treatment has been shown to increase the number of patients with no or minimal disability. However, it is unclear how much this improvement will translate into an improved outcome for patients. The number of patients treated with tPA corresponds to the NNT of 8.3; an additional patient would have to be treated to achieve a positive outcome. However, these improvements can be attributed to the new treatment and the growing interest in stroke care.

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However, the primary endpoint of this trial was the proportion of patients with favorable outcomes on the modified Rankin Scale. A favorable outcome was defined as a score of 0 or one on the scale. These studies have demonstrated that tPA can improve 90-day outcomes in patients with acute ischemic stroke. There was also no difference in mortality between the treatment group and the control group. In summary, tPA may help improve outcomes, but it is still premature to recommend it for stroke patients.

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Researchers also discovered that tPA can have pleiotropic effects in the brain. The drug inhibits nuclear factor (NF)-kB activation and activates the Akt protein, which is thought to be pro-survival. This study also demonstrated that tPA can lead to partial or complete reperfusion in about half of patients. The study found that the combination of tPA and PDTC increased sensorimotor and neurological functions.

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Although tPA is an effective treatment for acute ischemic stroke, it can lead to complications in patients who are not receiving it promptly. The risk of edema, HT, and reperfusion injury are greater with delayed tPA administration. Additionally, tPA also inhibits clotting factors, which can lead to further damage to the BBB. The new treatment, tPA, is only available in a single-dose dose for ischemic stroke.

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Despite the potential benefits of tPA, access to this drug remains a major barrier to its use. Studies have shown that 25% of AIS patients were not treated with tPA within three hours of their stroke symptoms. The American Stroke Association strongly encourages doctors to administer tPA as soon as symptoms appear. The study also found that physicians who are hesitant to administer tPA can be sued for malpractice. The authors also identified a number of other potential barriers to accessing this treatment for acute stroke.

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Although there are concerns about tPA safety in acute ischemic stroke, the FDA approved tPA for use in acute ischemic stroke patients. This treatment is controversial in some circles, but there are many advantages associated with it. The FDA also approved it for use in people with ischemic stroke. Despite this, many doctors and stroke specialists are still cautious about its use. In the meantime, research continues to assess the safety and efficacy of the drug.

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The lawsuit also alleges that the doctors failed to diagnose the patient properly, resulting in a missed opportunity to administer tPA. This argument has a tenuous foundation in the law. Failure to diagnose the patient properly, transfer the patient to a hospital that offered thrombolysis, and failing to obtain proper documentation and informed consent are among the reasons for the lawsuit. Ultimately, the plaintiffs are seeking compensation for the pain and suffering they have suffered as a result of the tPA treatment.

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