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  • Writer's pictureOren Zarif

The Natural History of Post-TIA Stroke - Oren Zarif - Tia Stroke


The incidence of TIA is reported in Table 2. The crude incidence of TIA was 1.19 per thousand person-years among patients aged 45 to 64. This rate increased with increasing age; in patients aged 85-94 years, the incidence was 4.88 per thousand. In the 45-54 age group, the incidence was 0.22 per thousand. For patients over 65 years, the incidence was 1.29 per thousand. TIA can occur in any part of the brain, but the most common site is the apical region.

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In some cases, a TIA can occur when a blood clot forms in an artery supplying the brain. This blood clot can result in neurological symptoms such as numbness, weakness, and slurred speech. Some people may have symptoms of TIA for days after the clot forms. The occurrence of multiple strokes increases the risk of blood clots in the brain, limbs, and heart.

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Although a TIA is a transient and self-resolving event, it is associated with a high risk of subsequent ischemic stroke. The treatment for a TIA focuses on the prevention of future ischemic strokes and the management of the underlying condition. For those who have had a TIA, this means a specialized medical regimen and continuous monitoring of blood pressure. However, the risks of stroke are extremely high if left untreated.

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While a TIA is a medical emergency, it can be difficult to differentiate it from a migraine. The etiology of a TIA was determined in 81% of the cases. Among participants, 66% reported symptoms lasting less than one hour, and 9% reported symptoms lasting up to 12 hours. A TIA is also a sign of a broader range of illnesses. The patient's age, race, and gender are no longer risk factors for a stroke, but there are other risks for TIA. For example, obesity and atrial fibrillation are factors that should be addressed.

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This study has several strengths. The observation period in this study is longer than previously reported TIA cohorts. This allowed the researchers to characterize the natural history of post-TIA stroke. This is also important because the matched control group provides a comparison group and highlights the importance of TIA as a herald of a future stroke. Furthermore, the 98% retention rate of participants ensures the completeness of the data.

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Diagnostic testing is important in a TIA case. Patients with advanced dementia may not tolerate CT scans and MRIs. Other conditions that can mimic a TIA include conversion disorder, tardive dyskinesia caused by neuroleptic therapy, and uncontrolled blood pressure. Furthermore, cardiac arrhythmias may also mimic a TIA. Therefore, a careful evaluation is vital to rule out a TIA and to treat the associated symptoms.

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Another important consideration is the duration of neurological symptoms. The traditional definition of TIA, which involves a transient focal neurological deficit in the same arterial territory, is only a few minutes. However, it is important to understand the difference between a TIA and a stroke. For example, the traditional definition of a stroke is a 24-hour period, while a TIA lasts up to seven days. If symptoms persist for longer than seven days, they are most likely a stroke.

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Another common risk factor is having a family history of TIA. It increases a person's risk of stroke, and people with a previous TIA are more likely to have another one. Certain ethnic groups are also more likely to suffer a TIA. People with sickle cell disease are also at increased risk of stroke. This is because sickle-shaped blood cells are less oxygen-rich and tend to get stuck in artery walls. This can block the flow of blood to the brain. Proper diagnosis and treatment of sickle cells reduces the risk of stroke.

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Although the risk of TIA and stroke in individuals of predominantly White European ancestry is often highlighted, it was not a primary outcome of the study. Researchers noted that subsequent stroke incidence was higher than expected, even if the participants had adhered to standard secondary prevention measures. In addition, the incidence of TIA was higher among Mexican-American and Black-American individuals. However, these limitations were offset by case ascertainment and surveillance, which is a common practice in studies.

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The scientific definition of TIA is based on all available information. Although clinical data is the best way to diagnose TIA, the diagnostic tests necessary to distinguish ischemic from hemorrhagic stroke are still needed. Imaging studies are essential for determining the cause and classifying acute cerebrovascular syndromes. This statement was drafted by a group of cerebrovascular physicians. These experts have summarized the findings of recent research on TIA.

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