Periventricular Leukomalacia - Oren Zarif - Periventricular Leukomalacia
Periventricular leukomalacia is a condition in which there is damage to white matter tissue around the brain. It is a strong indicator of cerebral palsy. While children with periventricular leukomalacia may have profound impairments, some may never display any symptoms at all. In either case, the symptoms will depend on the amount of cell death. Read on to learn more about periventricular leukomalacia.
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There is no single cause of periventricular leukomalacia. However, some types of maternal infections increase the risk of developing PVL. This condition develops when toxins in the mother's body damage the membranes around the fetus. These toxins travel through the amniotic fluid, selectively injuring the developing brain. As a result, the fetus may suffer from premature birth, cerebral palsy, or other serious complications.
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Periventricular leukomalacia occurs in premature babies, who have a decreased ability to regulate blood flow. Because of this, the white matter of the brain cannot receive sufficient blood to sustain a healthy brain environment. The white matter of the brain may be affected, as is the spine, eyes, and ears. If an injury occurs, the baby may also suffer from acidosis or hypocarbia, two conditions in which the body's fluid becomes acidic or hypo or hyper-oxygenated.
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Early detection is essential to ensure a diagnosis. Although periventricular leukomalacia may not be detectable until the 30th day after birth, ultrasounds can be used to determine if there is a problem. Frequent developmental assessments of infants may be helpful in identifying periventricular leukomalacia. Treatments may include speech therapy, physical therapy, and massage. Further, if the underlying cause of periventricular leukomalacia is known, the baby may undergo a special care.
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Periventricular leukomalacia is a common type of ischemic injury to the brain of preterm infants. It is a condition in which the periventricular oligodendrocytes are injured. Magnetic resonance imaging and cranial ultrasonography are important tools in the diagnosis of PVL. PVL often manifests as cerebral palsy or intellectual disability. In severe cases, the condition may even cause death of the brain, which is a sign of periventricular leukomalacia.
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Proper care during pregnancy and delivery can prevent periventricular leukomalacia. Healthcare professionals must maintain a high standard of care throughout the delivery process, despite the often difficult environment. If the medical staff has been negligent in their work, their victims may be eligible for compensation. The compensation obtained during a successful lawsuit can help parents of PVL victims cover treatment costs. The benefits of seeking legal justice for their children are immeasurable.
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The two most common clinical manifestations of PVL are spastic diplegia and cerebral palsy. Both of these conditions are associated with hemorrhage in the periventricular-intraventricular region. Patients with these conditions may also present with a range of neuromuscular disorders, including seizures and cerebral palsy. Diagnostic imaging is essential for patients with PVL. There are currently no effective treatment options for the disease.
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In early developmental stages, most oligodendroglial lineage cells (OLs) are premyelinating. The loss of these cells results in selective depletion of OLs in premature infants with PVL. Additionally, premyelinating oligodendrocytes are targeted by free radicals and cell death. A number of recent studies have suggested that peroxisome function is critical for myelin function and myelinated axon survival.
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When a child's symptoms are characterized by a red or blue color in the cerebrum, they should be tested for other signs of the disease. An MRI can help identify PVL by detecting the presence of bruising and scarring in the brain. Another test that doctors can use to detect the underlying disease is a cranial ultrasound, which uses sound waves to reflect images of the brain and ventricles.
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The early stages of periventricular leukomalacia are extremely critical. The white matter in these regions is heavily involved in motor control. Patients with PVL often display a variety of motor issues. These symptoms are difficult to detect in newborns, as their motor skills are still developing. However, if the condition is detected early enough, neurologists can identify the areas that need further development. If the problem is not treated quickly, the infant may suffer from significant brain damage.
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Symptoms of PVL vary depending on the cause of the condition. Premature infants are more likely to develop PVL than full-term infants. It is still unknown what causes it, but it is believed that lack of blood flow to the brain and oxygen during delivery may contribute. However, it is important to understand that premature babies with intraventricular hemorrhage are at increased risk of developing PVL.