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Periventricular Leukomalacia - Oren Zarif - Periventricular Leukomalacia
The condition is responsible for many of the developmental, cognitive, and motor disabilities found in premature infants. Periventricular leukomalacia is caused by intrauterine infections that affect the membranes surrounding the fetus. These toxins selectively damage the brain and cause premature membrane rupture. This disease can develop at any stage in the pregnancy, and research has helped identify the most vulnerable periods. In this article, we'll discuss some of the important aspects of this condition and what treatment is currently available.
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There are three types of PVL. Cystic and noncystic forms form a distinct and overlapping pattern. Cystic PVL causes macroscopic focal necrosis, while noncystic PVL causes microscopic glial scars. A third type of cerebral white matter abnormality is diffuse astrogliosis. These lesions in the white matter of the brain are responsible for most of the injuries seen in premature infants today.
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There are many causes of PVL. Some maternal infections may increase the risk of developing PVL. The release of toxins from the mother's system damages the membranes surrounding the developing fetus. These toxins travel through the amniotic fluid and selectively injure the developing brain. This can lead to premature membrane rupture and premature birth, as well as a number of other life-threatening complications.
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Early detection of this disease is crucial. In infants who are at risk of developing the condition, ultrasounds are vital to early diagnosis. Magnetic resonance imaging (MRI) and cranial ultrasound are two diagnostic procedures that can identify the condition. Early detection is crucial because it's difficult to detect this disease in infants. A newborn with PVL will need special care after discharge from the hospital. Various developmental tests will determine how well they're developing.
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Premature babies are particularly susceptible to PVL, since it occurs more often in premature babies. The disease causes damage to the cerebral white matter, which is responsible for transmitting nerve signals to muscles. It can cause motor disorders, delayed development, and vision impairment, so it's important to diagnose the condition as soon as possible. In some cases, premature infants may even suffer from coma or death. However, periventricular leukomalacia can be prevented.
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Although there are no certain cures for PVL, patients who experience it are often at risk of developing cerebral palsy. This condition can also lead to hemorrhage of the brain's periventricular areas, causing cerebral palsy. An ultrasound of the head can detect these problems early and help with treatment. If the disease is left untreated, it can cause permanent damage to the brain.
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A number of studies have indicated that maternal/fetal infections may induce OL death in PVL. Inflammation and cytokines can result from endotoxin. Evidence of endotoxin in PVWM injury has been found from epidemiological studies and neuropathologic analyses. However, it remains unclear how endotoxin plays a role in PVL development. In the meantime, research on the mechanisms of OL death in PVL is continuing.
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The onset of PVL in children is linked to prematurity and lack of cerebral blood flow. Therefore, medical professionals take precautions to prevent the disorder in children. Therapeutic hypothermia is sometimes used to prevent developmental delays and disabilities. In addition to medical care, pregnancy can reduce the risk of periventricular leukomalacia by avoiding exposure to high-risk environments and drugs and alcohol consumption. However, if the disease affects a pregnant woman, they should be closely monitored for other serious health problems.
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Cystic lesions in the lateral ventricles of the brain are caused by oxidative stress and damage from free radicals. The resulting lesion is a characteristic squared-off appearance of the posterior horns. This condition is often accompanied by degenerative complications in adulthood. There is also no cure for this condition. For now, it is regarded as a rare disease.
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MRI has a significant role in diagnosis of PVL. In neonatal patients, cranial ultrasonography can confirm the presence of focal PVL. However, in diffuse PVL, ultrasound and MRI cannot be used to make the diagnosis. MRI, however, can be used to identify ventriculomegaly and later myelin deficit in patients with periventricular leukomalacia. However, the availability of quality quantitative imaging data suggests that diffuse PVL is more prevalent.
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Premature infants are at increased risk for developing PVL. Up to sixty percent of them will develop cerebral palsy. The exact cause of this condition is unknown, but it is thought to be related to a lack of blood and oxygen in the brain's ventricles. This can happen if the baby is not delivered in time or a physician does not perform an emergency C-section. Even more, premature babies are prone to intraventricular hemorrhage.
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