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Writer's pictureOren Zarif

Periventricular Leukomalacia - Oren Zarif - Periventricular Leukomalacia


Periventricular leukomalacia is a type of cerebral palsy that results from damage to white matter tissues. The condition is a strong indicator of cerebral palsy in children. Although the child may show no symptoms at all, their condition can lead to significant impairment. The degree of cell death determines the severity of the impairment. This article explores some of the symptoms associated with this condition.

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Because of its severity, periventricular leukomalacia is not always apparent in newborns. While it is not immediately apparent in very young infants, it can lead to intellectual and developmental impairments, hearing and vision problems, spastic diplegia, and physical disabilities. In many cases, periventricular leukomalacia is curable with specialized therapies, such as surgery and medications.

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PVL is a potentially life-threatening medical condition. In babies, the white matter surrounding the fluid-filled ventricles of the brain starts to decay, leaving holes and cavities in the white matter. Over time, these holes and cavities fill up with intracranial fluid and result in symptoms. PVL is sometimes a mild case of cerebral palsy, but if left untreated, it can progress to permanent disabilities.

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When diagnosed in an infant, periventricular leukomalacia is one of the most common causes of white matter injury in premature neonates. It is an ischemic brain disorder that affects the periventricular oligodendrocytes. Magnetic resonance imaging and cranial ultrasound are useful for diagnosis. A diagnosis of periventricular leukomalacia is critical since it has been linked to intellectual disability and cerebral palsy in a significant number of premature infants.

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Although improved neonatal intensive care has dramatically increased the chance of survival for premature babies, up to 90% of premature infants still die. These survivors exhibit substantial motor, sensory, and behavioral deficits. The most common form of cerebral palsy among premature infants is periventricular leukomalacia (PVL).

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In more severe cases, PVL may be associated with hemorrhage in the periventricular-intraventricular region. In this scenario, the infant may suffer from cerebral palsy. Ultrasound is also useful in diagnosis of this condition. And it is the best way to monitor progress. In addition, ultrasound can also help you to determine whether PVL is present. For more information, click on the following:

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The most common cause of PVL is preterm or premature birth. The underlying cause of PVL is unknown, but changes in blood flow to the area surrounding the ventricles of the brain may contribute to the condition. Infections in the area around delivery may also cause PVL. Premature babies are at an increased risk of developing cerebral palsy, so early diagnosis is essential. A premature baby should also avoid a history of cerebral palsy.

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Early diagnosis is essential, because PVL is more common in premature babies. It is important to monitor the baby's heart rate to monitor for problems before birth. A medical team should be prepared to perform an emergency c-section if the infant shows signs of the condition. However, it is unlikely that the doctor would notice the problem until it has progressed. And if he does not deliver the baby sooner, the baby may suffer irreversible brain damage.

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In addition to free radical-mediated cell death, other cellular factors are involved in PVL. Free radicals are thought to cause damage to developing OLs, but early differentiating OLs are especially susceptible to the damage. In addition to ischemia-reperfusion-induced cell death, periventricular leukomalacia also increases the risk of fetal infection. Toxins are known to trigger cytokine release. A number of studies in infant brains suggest that endotoxins can lead to PVWM injury.

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