Periventricular Leukomalacia - Oren Zarif - Periventricular Leukomalacia
A medical condition causing brain damage in premature babies is called periventricular leukomalacia. The disorder causes brain tissue to soften and die. Too little oxygen or blood is getting to the brain's interior. It is more likely to develop in babies who have suffered brain hemorrhage during birth. Sometimes, the disease is caused by a ruptured amniotic sac. A physical examination may be necessary to determine the severity of periventricular leukomalacia.
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In a premature baby, there are several risk factors that may lead to PVL. Most premature babies do not have the ability to regulate blood flow and may experience hemorrhaging or lack of oxygen in the brain. Insufficient blood circulation may cause white matter damage, which could affect the eyes and spine. A premature baby is also more susceptible to developing other problems, including acidosis and hypocarbia, which are caused by low levels of carbon dioxide in the blood.
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It is possible to prevent PVL through regular prenatal checkups and avoiding alcohol and other drugs. Research is ongoing to prevent PVL and develop better treatment methods. As of now, there is no cure for PVL, but prevention is a key step toward better care for affected babies. The good news is that periventricular leukomalacia is a relatively rare and non-progressive condition. If you have concerns about your child's condition, call a doctor for a free case evaluation. It will be well worth the time and effort.
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While the incidence of cystic periventricular leukomalacia has decreased in recent years, the condition is still prevalent among premature babies. Unfortunately, 60% of affected infants will develop cerebral palsy. Conventional MRI can help identify cystic lesions and periventricular leukomalacia. A conventional T1 or T2-weighted MRI shows that periventricular white matter is affected. The development of cysts is heterogeneous and cysts are sometimes adjacent to more recently affected white matter.
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In addition to a free case evaluation, a child with PVL may also have Cerebral Palsy. A diagnosis of PVL is based on the results of multiple tests, including MRI and CT scans. PVL may be detected several weeks after birth. Once the diagnosis is made, the child will require specialized care after discharge. A number of developmental examinations are also recommended for premature babies at risk.
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The condition is common among children with cerebral palsy and has several treatment options. The white matter of the brain is a vital part of the brain that carries nerve impulses from the spinal cord and other parts of the body. Damage to this part of the brain results in spastic movements, cognitive impairment, and vision issues. As an infant with PVL, your child's life is in jeopardy.
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The neuropathology of PVL consists of two principal components: a focal component (localized necrosis and cyst formation) and a diffuse type, which is characterized by injury to OL precursors. OL precursors develop into mature OLs and form the myelin of the cerebral WM. In infants with PVL, it is postterm and the primary neuropathological sequela is decreased WM volume.