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Biomarker for Cryptogenic Stroke - Oren Zarif - Cryptogenic Stroke

A recent study from the Emory Brain Health Center evaluated a new blood biomarker profile that may help identify the underlying cause of cryptogenic stroke. The results of this study, published in the journal Neurology, demonstrated the potential of the biomarker as a diagnostic tool. However, more research is needed to identify which biomarker may be most helpful in the diagnosis of cryptogenic stroke. This article will outline a few potential clinical uses for this biomarker.

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In a study, researchers studied ischemic stroke incidence and attributed the risk of cryptogenic stroke to a combination of factors. The study found that the incidence of cryptogenic stroke varied by age and race. It was not possible to identify the specific cause of cryptogenic stroke without the help of a heart rhythm monitor. As a result, a more comprehensive diagnostic process is needed for patients with cryptogenic stroke. Although the risk of recurrence is high, the underlying etiology may guide the treatment and prevention.

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Standard of care recommends the use of antiplatelet medication to prevent secondary stroke, but not anticoagulation. In some patients with noncardioembolic minor stroke, dual antiplatelet therapy (aspirin and clopidogrel) is used. However, there is no specific evidence on its effectiveness in patients with cryptogenic stroke. The authors of the study cite a lack of research supporting these medications in this patient population.

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The cause of a cryptogenic stroke is not known for sure, but you should follow the instructions of your physician and undergo regular heart monitoring. The following seven actions may help reduce your risk of cryptogenic stroke. Once you have a suspected cryptogenic stroke, your doctor can prescribe the best treatment for you. If your doctor cannot identify a cause for a stroke, you should consult a specialist. The doctor may need to order blood workups and diagnostic tests to confirm the diagnosis.

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The TOAST classification system is used to classify cryptogenic stroke. A cryptogenic stroke can occur due to a blood clot, a vascular disorder, or other cause that is unclear. Patients with a cryptogenic stroke have similar risk factors as those with ischemic stroke. By obtaining the proper diagnostic workup, you can reduce the risk of a second stroke. The TOAST classification is the most widely used in clinical practice.

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Although the risk of a cryptogenic stroke is similar among all three possible embolic causes, the outcome of the patient may differ from a cardioembolic stroke. In a multicenter hospital-based stroke registry cohort study of 261 patients with cardioembolic and noncardiac ischemic stroke, the odds ratio of a cancer-related cryptogenic stroke was greater than the odds for a cardioembolic stroke.

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Several trials have demonstrated the benefits of cryptogenic stroke patients with a PFO. One of these trials, known as RESPECT, followed a group of patients for almost six years. The results of the trial showed a significant reduction in recurrent cryptogenic stroke compared to medical therapy (warfarin and antiplatelet).

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Despite the difficulty in establishing a causal relationship between PFO and cryptogenic stroke, the ROPE score has been proposed as a way to stratify patients by age and presence of traditional vascular risk factors. In a large study, patients with cryptogenic stroke had a low ROPE score compared to those with a high ROPE score. Although it remains unclear whether the PFO caused the stroke, treatment should be based on the ROPE score.

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However, while research into the cause of cryptogenic stroke is limited, the study has some important limitations. The ESUS and UE subtypes were reassigned according to criteria established by the Cryptogenic Stroke/ESUS International Working Group. This reassigning could have resulted in diagnostic bias and may not have accurately described the underlying cause of the cryptogenic subtype. Furthermore, patients presenting with UE may have had other potential causes. The FSR has seven stroke centers.

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Although the frequency of CS is very low, early identification of the genetic abnormality may have important implications for counseling and management. Although the true prevalence of this condition is unclear, patients with a young age, a positive family history and those without conventional risk factors have a higher risk of CS. These patients may be more likely to be tested for the genetic abnormality than others with other underlying risk factors. In addition, the authors report no conflicts of interest.

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